The role of glutathione for oxidative stress and pathogenicity of <i>Streptococcus suis</i>.

ABSTRACT: Streptococcus suis is an important zoonotic pathogen that threatens human and pig health. During infection, the host can impose oxidative stress to resist pathogen invasion. Resistance to oxidative toxicity is an important factor for pathogens. Glutathione synthesis contributes to reactive oxygen species (ROS) detoxification in bacterial cells. Little is known about the roles of glutathione synthesis and transport in S. suis. In this study, we demonstrated that glutathione treatment increased oxidative stress tolerance in S. suis. GshAB and GshT were found in S. suis glutathione synthesis and import by bioinformatics. In vitro, inactivation of gshAB and gshT led to increased sensitivity to oxidative stress. Inactivation of g

SUBMITTER: Peng W 

PROVIDER: S-EPMC11901377 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature