Synthesis and in vitro antitrypanosomatid activity of novel 5-nitroindole-rhodanine conjugates.

ABSTRACT:

Aim

Trypanosomatid diseases, leishmaniasis and trypanosomiasis are vector-borne parasitic diseases that can cause death and catastrophic economic losses for millions of people. The growing resistance of trypanosomatid parasites to current treatments highlights the urgent need for new therapeutic agents. This study explored 5-nitroindole-rhodanine conjugates to identify promising new compounds with the potential for future development as antitrypanosomatid treatments.

Materials and methods

The conjugates were synthesized in a multi-step process and evaluated in vitro for antileishmanial activity against Leishmania (L.) donovani and L. major strains. Cytotoxicity was assessed on Vero and THP-1 cells. Due to the taxonomic relation to Tr

SUBMITTER: Badenhorst E 

PROVIDER: S-EPMC11901381 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature