Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease.

ABSTRACT: Numerous studies have accelerated the knowledge expansion on the role of gut microbiota in inflammatory bowel disease (IBD). However, the precise mechanisms behind host-microbe cross-talk remain largely undefined, due to the complexity of the human intestinal ecosystem and multiple external factors. In this review, we introduce the interactome concept to systematically summarize how intestinal dysbiosis is involved in IBD pathogenesis in terms of microbial composition, functionality, genomic structure, transcriptional activity, and downstream proteins and metabolites. Meanwhile, this review also aims to present an updated overview of the relevant mechanisms, high-throughput multi-omics methodologies, different types of multi-omics cohort resources, and computational methods used to

SUBMITTER: Su F 

PROVIDER: S-EPMC11901428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature