Impact of Marasmic Malnutrition on Visceral Leishmaniasis: Progression and Treatment Efficacy in a Murine Model.

ABSTRACT:

Background/objectives

Malnutrition and visceral leishmaniasis are major public health problems that are responsible for millions of deaths across many countries. Leishmaniasis development and progression are associated with the host immune status. In this context, malnutrition can directly affect the course of leishmaniasis, impairing several components of the immune system. Moreover, malnutrition directly interferes with the tropism of Leishmania in organs, affecting host susceptibility. Therefore, this work aimed to evaluate the influence of nutritional status on the establishment, progression, and treatment of Leishmania infantum infection in malnourished and refed mice.

Methods

BALB/c mice were fed either a control or restricted diet, infected with L. in

SUBMITTER: Ferreira-Paes T 

PROVIDER: S-EPMC11901435 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature