Relationships Between Diet and Geographic Atrophy Progression in the Age-Related Eye Diseases Studies 1 and 2.

ABSTRACT: Background/Objectives: The objective of this study was to analyze the relationships between diet and geographic atrophy (GA) progression, both area-based and proximity-based, for dietary pattern, components, and micronutrients. Methods: In the Age-Related Eye Diseases Study (AREDS) and AREDS2, an Alternative Mediterranean Diet Index (aMedi), its nine components, and individual micronutrient intakes were calculated. Mixed-model regression was performed for square root GA area, GA foveal proximity, and acuity. Results: The study populations comprised 657 (AREDS) and 1179 eyes (AREDS2). For area-based progression, a higher aMedi was associated with slower progression in AREDS2 and (in analyses excluding MUFA:SFA) AREDS. A higher intake was associated with slower progressi

SUBMITTER: Agron E 

PROVIDER: S-EPMC11901604 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature