Yerba Mate (<i>Ilex paraguariensis</i>) Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Regulatory T Cell Function.

ABSTRACT: Background/Objectives: In Latin America, yerba mate (YM) is a popular infusion processed from the leaves and stems of Ilex paraguariensis. YM has been shown to have anti-inflammatory properties in several studies, although the effect of YM on multiple sclerosis (MS) remains elusive. The purpose of this study was to examine the effect of YM on the development of MS, by using the experimental autoimmune encephalomyelitis (EAE) mouse model while also evaluating its effect over infiltration of immune cells into the central nervous system (CNS) and regulatory T cell (Treg) function. Methods: YM or vehicle were administrated to mice daily by oral gavage for seven days prior to EAE induction and during the entire course of the disease. EAE score was recorded daily, and immune

SUBMITTER: Herrada AA 

PROVIDER: S-EPMC11901674 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature