Bioassay-Guided Isolation of Piplartine from <i>Piper purusanum</i> Yunck (Piperaceae) and Evaluation of Its Toxicity Against <i>Aedes aegypti</i> Linnaeus, 1762, <i>Anopheles darlingi</i> Root, 1926 (Culicidae), and Non-Target Animals.

ABSTRACT: Aedes aegypti and Anopheles darlingi are the primary vectors of dengue and malaria in Brazil. Natural products are currently regarded as promising alternatives for their control, offering environmentally friendly solutions for larval management due to their low toxicity to non-target organisms. Thus, Piplartine, isolated for the first time from Piper purusanum, exhibited larvicidal activity against Ae. aegypti and An. darlingi (LC₅₀ of 14.56 and 26.44 μg/mL), occasioned by the overproduction of reactive oxygen and nitrogen species (66.67 ± 7% and 86.33 ± 6%). Furthermore, piplartine enhanced the activity of key detoxifying enzymes, including catalase (87.00 ± 9 and 94.67 ± 9 μmol of H₂O₂ consumed per minute per mg of prote

SUBMITTER: de Oliveira AC 

PROVIDER: S-EPMC11901690 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature