Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age.

Results

Out of 7776 genes, 1735 were differentially expressed between mdx and control muscle at at least one timepoint (p < 0.05 after Bonferroni correction). We found that genes coding for components of the dystrophin-associated glycoprotein complex are generally downregulated in the mdx mouse. Based on functional characteristics such as membrane localization, signal t

SUBMITTER: Turk R 

PROVIDER: S-EPMC1190170 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature