Synthesis, Characterization, and Evaluation of the Antifungal Properties of 3-Indolyl-3-Hydroxy Oxindole Derivatives Against Plant Pathogenic Fungi.

ABSTRACT: To discover novel fungicides with good inhibitory effects on plant fungal diseases, twenty-five 3-indolyl-3-hydroxy oxindole derivatives (3a-3y) were synthesized. These newly derivatives were characterized by NMR and HRMS. Their antifungal activities against five plant pathogenic fungi were assessed in vitro. Most of the compounds exhibited moderate to excellent antifungal activities against the five pathogenic fungi. Notably, compounds 3t, 3u, 3v, and 3w displayed remarkable and broad-spectrum antifungal activities comparable to or superior to those of the fungicides carvacrol (CA) and phenazine-1-carboxylic acid (PCA). Among them, compound 3u displayed the most excellent antifungal activity against Rhizoctonia solani Kühn (R. solani), with

SUBMITTER: Bai Z 

PROVIDER: S-EPMC11901744 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature