Association study of functional genetic variants of innate immunity related genes in celiac disease.

ABSTRACT:

Background

Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD) pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition.

Methods

We performed a familial study in which 105 celiac families characterized by the presence of an affected child with CD were genotyped for functional polymorphisms located at regulatory regions of IL-1alpha, IL-1beta, IL-1RN, IL-18, RANTES and MCP-1 genes. Familial data was analysed with a transmission disequilibrium test (TDT) that revealed no statistically significant differences in the transmission pattern of the different genetic markers considered.

Results

The TDT a

SUBMITTER: Rueda B 

PROVIDER: S-EPMC1190178 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature