Glutathione Contributes to Caloric Restriction-Triggered Shift in Taurine Homeostasis.

ABSTRACT:

Background/objectives

Previously, we found that caloric restriction (CR) in mice increases taurine levels by stimulating hepatic synthesis, secretion into the intestine and deconjugation of taurine-conjugated bile acids (BA). Subsequently, in the intestine, taurine conjugates various molecules, including glutathione (GSH). The current study explores the mechanisms behind forming taurine-GSH conjugate and its consequences for taurine, other taurine conjugates, and BA in order to improve understanding of their role in CR.

Methods

The non-enzymatic conjugation of taurine and GSH was assessed and the uptake of taurine, GSH, and taurine-GSH was verified in five sections of the small intestine. Levels of taurine, gavaged ¹³C labeled taurine, taurine conjugates, taurine-

SUBMITTER: Gregor A 

PROVIDER: S-EPMC11901847 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature