Supporting islet function in a PVDF membrane based macroencapsulation delivery device by solvent non-solvent casting using PVP.

ABSTRACT: Type 1 diabetic (T1D) patients are life-long dependent on insulin therapy to keep their blood glucose levels under control. An alternative cell-based therapy for exogenous insulin injections is clinical islet transplantation (CIT). Currently the widespread application of CIT is limited, due to risks associated with the life-long use of immunosuppressive drugs to prevent rejection of donor cells. An immunoprotective macroencapsulation device can protect allogeneic islet cells against the host immune system and allow exploring extrahepatic transplantation sites. We report on the characterization and creation of porous polyvinylidene fluoride (PVDF) membrane-based devices intended for islet and beta-cell transplantation. We hypothesize that by incorporating polyvinyl-pyrrolidone (PVP) into a

SUBMITTER: de Bont DFA 

PROVIDER: S-EPMC11902058 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature