Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort.

ABSTRACT:

Background

The actual relationship between viral variability and HIV disease progression and/or non-progression can only be extrapolated through epidemiologically-linked HIV-infected cohorts. The rarity of such cohorts accents their existence as invaluable human models for a clear understanding of molecular factors that may contribute to the various rates of HIV disease. We present here a cohort of three patients with the source termed donor A--a non-progressor and two recipients called B and C. Both recipients gradually progressed to HIV disease and patient C has died of AIDS recently. By conducting 15 near full-length genome (8.7 kb) analysis from longitudinally derived patient PBMC samples enabled us to investigate the extent of molecular factors, which govern HIV disease progre

SUBMITTER: Mikhail M 

PROVIDER: S-EPMC1190217 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature