27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in <i>Caenorhabditis elegans</i> by Activating Nuclear Receptors.

ABSTRACT: 27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show that 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), a nuclear receptor transcription factor, extending the lifespan and healthspan in Caenorhabditis elegans (C. elegans). Meanwhile, the longevity-promoting effect of 27-HMA was attenuated in the mutants of nhr-8 and daf-12, the FXR homologs, indicating that the longevity effects of 27-HMA in C. elegans may depend on nuclear hormone receptors (NHRs). Further analysis revealed potential associations between the longevity effects of 27-HMA and the insulin/insulin-like growth factor-1 signaling (IIS)/TORC1 pathway. Moreover, 27-HMA increa

SUBMITTER: Gao X 

PROVIDER: S-EPMC11902184 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature