Urinary Iodine Concentration and Thyroid Hormone Metabolism in Pregnant Women and Neurodevelopment in Their Children: A Longitudinal Canadian Birth Cohort.

ABSTRACT: Background/Objectives: Iodine is essential for thyroid hormone (TH) synthesis, and THs in pregnant women are critical for fetal brain development. It is unclear whether urinary iodine concentrations (UICs) are associated with thyroid parameters in pregnant women and neurodevelopment in their 3-4-year-old children. Methods: In the Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) cohort, we categorized UIC adjusted for urinary creatinine (UIC/Cr) in the first two trimesters as <150, 150-500, or ≥500 µg/g. We used multivariable regression to quantify associations between UIC/Cr and thyroid parameters in maternal plasma (n = 1501), including thyroid stimulating hormone (TSH), total T4 (tT4), free T4 (fT4), thyroglobulin (Tg) and Tg antibodies (TgAb), an

SUBMITTER: Berghuis SA 

PROVIDER: S-EPMC11902198 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature