The causal effects of inflammatory bowel disease on its ocular manifestations: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.

Methods

We performed a two-sample MR analysis with public genome-wide association studies (GWAS) data. Eligible instrumental variables (IVs) were selected according to the three assumptions of MR analysis. The inverse-variance weighted (IVW) method was the main method. Complementary methods included the MR-Egger regression, the Weighted Median, the

SUBMITTER: Luo L 

PROVIDER: S-EPMC11902285 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature