Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis.

ABSTRACT:

Background and aims

Alcohol-associated hepatitis (AH) is a clinically severe, acute disease that afflicts only a fraction of patients with alcohol use disorder. Genomic studies of alcohol-associated cirrhosis (AC) have identified several genes of large effect, but the genetic and environmental factors that lead to AH and AC, and their degree of genetic overlap, remain largely unknown. This study aims to identify genes and genetic variations that contribute to the development of AH.

Approach and results

Exome-sequencing of patients with AH (N=784) and heavy drinking controls (N=951) identified an exome-wide significant association for AH at patalin-like phospholipase domain containing 3, as previously observed for AC in genome-wide association study, although with a much lowe

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC11902603 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature