Perinatal outcomes among pregnant women with HIV initiating antiretroviral therapy preconception and antenatally.

ABSTRACT:

Objective

Increasingly, pregnant women with HIV (WHIV) initiate antiretroviral therapy (ART) before conception. We assessed the risk of adverse perinatal outcomes among pregnant WHIV initiating ART preconception or antenatally, compared with women without HIV or ART-naive WHIV.

Design

Systematic review and meta-analysis.

Methods

We searched PubMed, EMBASE, CINAHL, and Global Health for studies published between 1 January 1980 and 14 July 2023. We assessed the association of preconception/antenatal ART initiation with preterm birth (PTB), very PTB (VPTB), spontaneous PTB (sPTB), low birthweight (LBW), very LBW (VLBW), small for gestational age (SGA), very SGA (VSGA), stillbirth and neonatal death (NND). Data were analysed using random effects meta-analyses. Quality ass

SUBMITTER: Boering P 

PROVIDER: S-EPMC11902611 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature