Dysregulated metabolic pathways associated with air pollution exposure and the risk of autism: Evidence from epidemiological studies.

ABSTRACT: Autism spectrum disorder (ASD) is a developmental disorder with symptoms that range from social and communication impairments to restricted interests and repetitive behavior and is the 4th most disabling condition for children aged 5-14. Risk factors of ASD are not fully understood. Environmental risk factors are believed to play a significant role in the ASD epidemic. Research focusing on air pollution exposure as an early-life risk factor of autism is growing, with numerous studies finding associations of traffic and industrial emissions with an increased risk of ASD. One of the possible mechanisms linking autism and air pollution exposure is metabolic dysfunction. However, there were no consensus about the key metabolic pathways and corresponding metabolite signatures in mothers and chi

SUBMITTER: Kang N 

PROVIDER: S-EPMC11902886 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature