Gut microbiota and osteonecrosis: A Mendelian randomization study.

ABSTRACT: Emerging evidence indicates an association between the gut microbiota and the incidence of osteonecrosis (ON), yet the literature has not adequately addressed whether this relationship is causal. This study uses data from the MiBioGen Consortium and the UK Biobank for Mendelian randomization (MR) analysis to identify pathogenic gut microbial taxa associated with ON. Sensitivity analyses confirmed causal relationships, while reverse MR ruled out reverse causation. SNP annotation located genetic variants linked to gut microbiota instrumental variables in ON. The inverse variance weighted method revealed 5 microbial taxa with a causal association with ON, including the order Erysipelotrichales (OR = 2.24, 95% CI = 1.16-4.32, P = .02), genus Christensenellaceae R (OR = 0.41, 95% CI = 0.19-0.87

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11902940 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature