Comprehensive causal analysis between autoimmune diseases and glioma: A Mendelian randomization study.

ABSTRACT: The causal association between the autoimmune disease and the development of glioma and its subtypes remains unclear. We performed a comprehensive Mendelian randomization (MR) to clarify their causal association from genetic perspective. We obtained the summary-level datasets for autoimmune diseases from recently published genome-wide association studies in the UK Biobank (UKB) and the FinnGen consortium. Additionally, we collected summary statistics datasets related to glioma and its subtypes from a comprehensive meta-analysis genome-wide association study, which included 12,488 cases and 18,169 controls. We primarily used inverse variance weighting method, supplemented by Bonferroni correction to account for multiple tests to reduce the probability of false positive results. We also perf

SUBMITTER: Deng N 

PROVIDER: S-EPMC11902947 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature