Identification of potential biomarkers associated with oxidative stress in the pathogenesis of pre-eclampsia.

ABSTRACT: Pre-eclampsia (PE) is a multisystem pregnancy disorder characterized by placental and maternal endothelial dysfunction, and affects approximately 5% to 7% of pregnancies worldwide, leading to significant maternal and neonatal morbidity and mortality. Mounting evidence indicates that placental oxidative stress (OS) plays a critical role in the pathogenesis of PE. However, the specific mechanisms associated with OS during the occurrence and progression of PE remain largely unknown. Thus, we aimed to identify the key molecules associated with OS and explore their potential mechanisms in PE. Transcriptome data were downloaded from the Gene Expression Omnibus database, including 80 PE and 77 normal placental tissues. OS-related genes were identified using the Gene Ontology database. Gene Ontolo

SUBMITTER: Liu X 

PROVIDER: S-EPMC11902957 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature