Exploring metabolite-mediated links between lipidome and deep vein thrombosis: Insights from Mendelian randomization analysis.

ABSTRACT: The aim was to investigate the causal relationship between the lipidome and deep vein thrombosis (DVT) while identifying and quantifying the role of metabolites as potential mediators. Two-sample Mendelian randomization (MR) analysis of lipid species (n = 7174) and DVT (6767 cases and 330,392 controls) was performed using pooled data from genome-wide association studies. In addition, we quantified the proportion of metabolite-mediated lipidomic effects on DVT using 2-step MR. Phosphatidylcholine (18:0_18:2) levels mined from 179 lipids using MR analysis reduced the risk of DVT (odds ratio [OR]: 0.997; 95% CI: 0.996-0.999; P = 4.25 × 10-4; false discovery rate [FDR] = 0.013). Octadecadienedioate (C18:2-DC) levels increased with the increasing phosphatidylcholine (18:0_18:2) levels (OR: 1.08

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11902998 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature