Optimized gene-enhanced ERA improves in vitro fertilization outcomes in patients with repeated implantation failure: A meta-analysis.

ABSTRACT:

Background

Assisted reproductive technology still presents a significant challenge when it comes to repeated implantation failure (RIF). To address this issue, personalized embryo transfer (pET) has been suggested as a potential solution. pET involves guiding the embryo transfer process based on an analysis of endometrial receptivity, known as endometrial receptivity analysis (ERA). However, the clinical value of this approach remains uncertain.

Methods

We conducted a comprehensive analysis of 14 studies pertaining to pET guided by ERA in patients with RIF. The outcomes evaluated in these studies encompassed the clinical pregnancy rate (CPR), implantation rate, and live birth rate (LBR). In addition, we performed subgroup analysis by considering different definitions of RIF

SUBMITTER: Song T 

PROVIDER: S-EPMC11903006 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature