Hippocampal volume asymmetry in Alzheimer disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Biomarkers play an important role in the diagnosis of early-stage Alzheimer disease (AD), with the hippocampal emerging as the most reliable indicator of AD pathology. Elucidation of the patient's left and right hippocampal volumes warrants further consideration. Therefore, caution should be exercised regarding the constraints inherent in the measurement method. This meta-analysis aimed to determine the left and right hippocampal volume changes and the volume measurement method.

Methods

The PubMed, Web of Science, and Scopus databases were searched and published until September 2023. A total of 29 studies were included in this meta-analysis.

Results

The meta-analysis results indicate a significant reduction in total hippocampal volume in AD patients. The re

SUBMITTER: Pusparani Y 

PROVIDER: S-EPMC11903023 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature