Assessing causality between mitochondrial-associated proteins with musculoskeletal diseases: A Mendelian randomization study.

ABSTRACT: Musculoskeletal diseases are the leading cause of disability-adjusted life years. Mitochondria, often referred to as the "powerhouses" of cells, are believed to play a role in regulating cellular metabolism and differentiation, potentially influencing the occurrence and progression of musculoskeletal diseases. However, the exact causal relationships remain to be defined. This study aimed to investigate the causal relationships between mitochondrial biological functions and musculoskeletal diseases (including osteoarthritis (OA), osteoporosis, rheumatoid arthritis (RA), and ankylosing spondylitis through Mendelian randomization (MR) analysis). We systematically summarized data related to mitochondrial functional proteins and musculoskeletal diseases from the IEU OpenGWAS and UK Biobank data

SUBMITTER: Li JC 

PROVIDER: S-EPMC11903026 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature