Noradrenergic and Dopaminergic modulation of meta-cognition and meta-control.

ABSTRACT: Humans and animals use multiple control systems for decision-making. This involvement is subject to meta-cognitive regulation - as a form of control over control or meta-control. However, the nature of this meta-control is unclear. For instance, Model-based (MB) control may be boosted when decision-makers generally lack confidence as it is more statistically efficient; or it may be suppressed, since the MB controller can correctly assess its own unreliability. Since control and metacontrol are themselves subject to the influence of neuromodulators, we examined the effects of perturbing the noradrenergic (NE) and dopaminergic (DA) systems with propranolol and L-DOPA, respectively. We first administered a simple perceptual task to examine the effects of the manipulations on meta-cognitive ab

SUBMITTER: Ershadmanesh S 

PROVIDER: S-EPMC11903042 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature