Nuclear morphological characterisation of lobular carcinoma variants: a morphometric study.

ABSTRACT:

Background and aims

Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective. This study aims to refine LC's cytonuclear features, focusing on pLC.

Methods

Whole slide images of 59 LCs, including both in situ (LCIS) and invasive (ILC) lesions, were analysed. Nuclear measurements, including nuclear size and variability, were scored using QuPath image analysis software. For comparison, selected features were scored in normal cells (n = 10) and pleomorphism score-matched invasive breast carcinoma (IBC) of NST type (n = 33). Additional visual assessment of the pleomorphic ILC (pIL

SUBMITTER: Katayama A 

PROVIDER: S-EPMC11903112 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature