The value of targeted CXCR4 ¹⁸F-AlF-NOTA-pentixafor PET/CT for subtyping primary aldosteronism.

ABSTRACT:

Objective

The study aimed to investigate the diagnostic value of ¹⁸F-AlF-NOTA-Pentixafor PET/CT in subtyping primary aldosteronism (PA).

Methods

This study enrolled 88 patients with PA or nonfunctional adenoma (NFA) for ¹⁸F-Pentixafor PET/CT scan. Of these, 20 patients underwent adrenal venous sampling (AVS), and 65 underwent adrenalectomy and postoperative follow-up.

Results

In 88 patients, 76 were diagnosed with unilateral PA (UPA), 4 were diagnosed with bilateral PA (BPA), and 8 were diagnosed with NFA, resulting in a total of 95 lesions. To identify UPA, visual analysis received a specificity of 94.12% and a sensitivity of 89.74%. The optimal cutoff values for SUV_max at 5.45, the lesion-to-normal adrenal ratio (LAR) at 1.43, and le

SUBMITTER: Peng Y 

PROVIDER: S-EPMC11903271 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature