Multitargeted biological actions of polydatin in preventing pseudogout acute attack.

ABSTRACT:

Introduction

We have recently shown that polydatin (PD) prevents calcium pyrophosphate (CPP) crystal-induced arthritis in mice. This study aims to explore potential mechanisms of action associated with this anti-inflammatory effect.

Materials and methods

Acute arthritis was induced in Balb/c mice by the injection of crystals into the ankle joint. Animals were randomised to receive PD or colchicine according to a prophylactic protocol. Ankle swelling was measured and both joints and muscles were harvested at sacrifice. Histological evaluations were performed using H&E staining to assess cartilage and muscle damage. Kondziela's inverted test was used to assess muscle strength. An exploratory protein array was performed on joint tissue to identify relevant inflammatory pathways

SUBMITTER: Baggio C 

PROVIDER: S-EPMC11903430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature