Ontology highlight
ABSTRACT:
SUBMITTER: Archambault V
PROVIDER: S-EPMC1190345 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Archambault Vincent V Ikui Amy E AE Drapkin Benjamin J BJ Cross Frederick R FR
Molecular and cellular biology 20050801 15
Eukaryotes replicate DNA once and only once per cell cycle due to multiple, partially overlapping mechanisms efficiently preventing reinitiation. The consequences of reinitiation are unknown. Here we show that the induction of rereplication by mutations in components of the prereplicative complex (origin recognition complex [ORC], Cdc6, and minichromosome maintenance proteins) causes a cell cycle arrest with activated Rad53, a large-budded morphology, and an undivided nucleus. Combining a mutati ...[more]