Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma.

ABSTRACT:

Objectives

Ferroptosis and cuproptosis can be summarized as metal-dependent cell death. This study aimed to explore the expression of metal-dependent cell death resistance (MCDR) characteristics in tumor cells of oral squamous cell carcinoma (OSCC) and to explore its relationship with lymph node metastasis (LNM).

Methods

By integrating single-cell data of OSCC from public databases, an expression matrix comprising 127,149 cells was constructed. Gene set scores were calculated using the irGSEA package, and GO and KEGG analyses were performed to identify enriched pathways. The R package monocle3 was employed to calculate the cell trajectory and infer evolutionary patterns. The MuSiC2 package was employed to enable the evaluation of cell proportions. Cell-cell interaction infor

SUBMITTER: Liu XH 

PROVIDER: S-EPMC11903458 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature