Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study.

ABSTRACT:

Purpose

Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association with clinical outcomes in these patients.

Methods

An international, prospective, multicenter, observational study was conducted across 74 ICUs in 26 countries, including adult patients with ABI (e.g., traumatic brain injury, intracranial hemorrhage, subarachnoid hemorrhage, and acute ischemic stroke), who required ICU admission and invasive mechanical ventilation. Ventilatory settings were recorded daily during the first week and on days 10 and 14. ICU and 6-months mortality and 6-months neurological outcome were evaluated.

Results

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SUBMITTER: Robba C 

PROVIDER: S-EPMC11903615 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature