Spatial-demographic analysis model for brain metastases distribution.

ABSTRACT:

Purpose

The distribution analysis of the morphologic characteristics and spatial relations among brain metastases (BMs) to guide screening and early diagnosis.

Material and methods

This retrospective study analysed 4314 BMs across 30 brain regions from MRIs of 304 patients. This paper proposed a unified analysis model based on persistent homology (PH) and graph modelling to provide a comprehensive portrait of BMs distribution. Spatial relationships are quantified through dynamic multiple-scale graphs constructed with Rips filtration. The multi-scale centrality importance and clustering coefficients are extracted to decode BMs spatial relations. Morphologic BMs characteristics are further analysed by varying radius and volume values that are considered as clinically influenti

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11903647 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature