Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice.

ABSTRACT:

Introduction

Glutamate represents the dominant neurotransmitter that conveys the light information to the brain, including the suprachiasmatic nucleus (SCN), the central pacemaker for the circadian system. The neuronal and astrocytic glutamate transporters are crucial for maintaining efficient glutamatergic signaling. In the SCN, glutamatergic nerve terminals from the retina terminate on vasoactive intestinal polypeptide (VIP) neurons, which are essential for circadian functions. To date, little is known about the role of the core circadian clock gene, Bmal1, in glutamatergic neurotransmission of light signal to various brain regions.

Methods

The aim of this study was to further elucidate the role of Bmal1 in glutamatergic neurotransmission from the retina to the SCN. We the

SUBMITTER: Korkmaz H 

PROVIDER: S-EPMC11903712 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature