LncRNA of peripheral blood mononuclear cells: HYMAI acts as a potential diagnostic and therapeutic biomarker for female major depressive disorder.

ABSTRACT:

Introduction

As a common and complex mental disorder, major depressive disorder (MDD) has brought a huge burden and challenges globally. Although the incidence of female MDD is twice that of male MDD, there are still no accurate diagnostic and treatment criteria for female MDD. The potential of long non-coding RNAs (lncRNAs) as efficient and accurate diagnostic and therapeutic biomarkers provides more possibilities for early and accurate diagnosis of MDD.

Methods

First, the differential expression profile of lncRNAs in peripheral blood mononuclear cells (PBMCs) between MDD patients and healthy controls was established based on high-throughput sequencing analysis. Then, the potential biomarker was screened out by quantifying differentially expressed lncRNAs based on quantitat

SUBMITTER: Bu T 

PROVIDER: S-EPMC11903756 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature