Overexpressed Wnt-7a acts as a potential antitumor immune modulator and predicts poor prognosis in HNSCC.

ABSTRACT: Immune checkpoint inhibitor (ICI) has become the first-line treatment of advanced head and neck squamous cell carcinoma (HNSCC), which has a relatively poor clinical prognosis and high mortality. However, only a proportion of patients respond well to ICI therapy. Identifying reliable predictive markers and potential targets to enhance the efficacy of ICI is of great importance. In this study, we systematically screened potential genes related to poor prognosis in HNSCC and Wnt-7a was selected based on results from multiple databases. Wnt-7a was overexpressed in HNSCC tissues and was associated with shorter overall survival. Human tissue samples and further bioinformatic analysis showed that Wnt-7a may be expressed in T cells and inhibited the infiltration and function of cytotoxic T cell r

SUBMITTER: Jiang HC 

PROVIDER: S-EPMC11903893 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature