La Sota-vectored recombinant vaccine with chimeric hemagglutinin-neuraminidase for enhanced protection against highly pathogenic pigeon paramyxovirus type 1.

ABSTRACT: Pigeon Paramyxovirus Type 1 (PPMV-1), an antigenic and host variant of the Newcastle Disease Virus (NDV), can infect pigeons of all ages and cause severe economic losses in the poultry industry. The existing commercial vaccines are not capable of providing complete protection against the prevalent PPMV-1 strains. To address this issue, reverse genetic technology was employed to create a recombinant 167DM strain by incorporating the chimeric genotype Ⅵ hemagglutinin-neuraminidase (HN) with La Sota as the backbone. The optimal anti-PPMV-1 vaccine candidate was identified through a systematical comparison of biological characteristics and immune efficacy of the predominant PPMV-1 epidemic strain, the 167DM strain, and the La Sota strain. Results indicated that the 167DM strain exhibited the h

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11903895 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature