The causal relationships between inflammatory cytokines, blood metabolites, and thyroid cancer: a two-step Mendelian randomization analysis.

ABSTRACT:

Background

Thyroid cancer is a prevalent malignant tumor, especially with a higher incidence in women. Tumor microenvironment changes induced by inflammation and alterations in metabolic characteristics are critical in the development of thyroid cancer. Nevertheless, their causal relationships remain unclear.

Methods

We utilized thyroid cancer GWAS data from the Global Biobank Meta-Analysis Initiative and GWAS data of 91 inflammatory cytokines and 1400 blood metabolites obtained from the GWAS Catalog to evaluate the causality between inflammatory cytokines, blood metabolites, and thyroid cancer using Mendelian randomization (MR). Initially, we identified inflammatory cytokines having a significant causal effect on thyroid cancer. Subsequently, for the identified positive blo

SUBMITTER: Liu W 

PROVIDER: S-EPMC11904021 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature