LST1 expression correlates with immune infiltration and predicts poor prognosis in acute myeloid leukemia.

ABSTRACT: Clinical management of acute myeloid leukemia (AML) poses significant challenges due to its poor prognosis and heterogeneous nature. Discovering new biomarkers is crucial for improving risk assessment and customizing treatment approaches. While leukocyte-specific transcript 1 (LST1) is implicated in inflammation and immune regulation, its function in AML remains ambiguous. In this investigation, we conduct a comprehensive investigation into LST1 expression profiles, clinical implications, functional pathways, and immune interactions in AML, leveraging multi-omics data and experimental validations. Our examination shows increased levels of LST1 expression in AML when compared to regular hematopoietic tissues, a discovery validated by RT-qPCR and Western blot analyses in a separate group. El

SUBMITTER: Xu H 

PROVIDER: S-EPMC11904058 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature