Causal relationship and potential common pathogenic mechanisms between hidradenitis suppurativa and related cancer.

ABSTRACT:

Background

Hidradenitis suppurativa (HS) is a chronic, inflammatory and common skin disease. Observation studies have reported the association between HS and cancers, however no studies reported whether a causal relationship exists between HS and cancers. This study aimed to explore the causal relationship between HS and differential subtypes of cancers by conducting a bidirectional Mendelian randomization (MR) analysis.

Method

Genome-wide association study (GWAS) data related to HS and 16 subtypes of cancers were collected. The inverse variance weighted (IVW) method was primarily applied for our MR analysis, MR-Egger, weighted median, simple mode, and weighted mode methods were used additionally. Heterogeneity, horizontal pleiotropy, and potential outliers were assessed for

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC11904070 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature