Development of an atherosclerosis rabbit model to evaluate the hemodynamic impact of extracorporeal circulation.

ABSTRACT:

Background

Aortic atherosclerosis increases the risk of embolic events under extracorporeal circulation (ECC). To evaluate the hemodynamic impact of ECC on atheromatous plaques, an atherosclerosis animal model, which is also eligible for ECC, is required.

Methods

Twenty-nine New Zealand White rabbits received a pro-atherosclerotic diet (group diet, n = 10), a pro-atherosclerotic diet and additional intraaortic balloon insufflation injury (group BI, n = 9), or served as controls (n = 10). After 3 or 6 months, aortic explants were analyzed by (immuno-)histology and RT-PCR.

Results

Blood serum analyses revealed increased cholesterol-levels in groups diet and BI compared to controls (3 months: p = 0.03 each, 6 months: p < 0.0001 each). Aortic inflammatory infiltration was

SUBMITTER: Assmann AK 

PROVIDER: S-EPMC11904102 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature