HC-A solution limb perfusion alleviates liver damage induced by limb ischemia-reperfusion injury in pigs.

ABSTRACT:

Background

The aim of the study was to explore a feasible method for alleviating limb ischemia-reperfusion injury (LI/RI) through the use of a high-concentration citrate solution (HC-A solution) for limb perfusion (LP).

Methods

Eighteen pigs were divided into three groups: the Sham group, LI/RI group, and HCA group. The Sham group underwent exposure of the iliac artery and vein. The LI/RI group underwent tourniquet placement and clamping of the iliac artery and vein to simulate LI/RI. The HCA group received HC-A solution LP for 30 min through the left iliac artery below the level of blood flow occlusion based on the LI/RI group. Oxidative stress markers and inflammatory response markers were compared among the three groups.

Results

Compared to the LI/RI group, the HCA

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11904103 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature