Ischemia-reperfusion injury after spinal cord decompressive surgery-An in vivo rat model.

ABSTRACT:

Background

Although decompression surgery is the optimal treatment for patients with severe degenerative cervical myelopathy (DCM), some individuals experience no improvement or even a decline in neurological function after surgery, with spinal cord ischemia-reperfusion injury (SCII) identified as the primary cause. Spinal cord compression results in local ischemia and blood perfusion following decompression is fundamental to SCII. However, owing to inadequate perioperative blood flow monitoring, direct evidence regarding the occurrence of SCII after decompression is lacking. The objective of this study was to establish a suitable animal model for investigating the underlying mechanism of spinal cord ischemia-reperfusion injury following decompression surgery for degenerative cervi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11904113 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature