An investigation into the mechanism for Kaempferol improving melanocyte death based on network Pharmacology and experimental verification.

ABSTRACT: Melanocyte (MC) death represents the basic pathological change of vitiligo. Kaempferol (Kae) is one of the main active ingredients of Tribulus terrestris, which is a commonly used Chinese medicine in the treatment of vitiligo. However, it remains unclear whether Kae can improve MC death, and hence relevant mechanisms need to be further explored. Therefore, we aimed to investigate the effect of Kae on MC death and relevant mechanisms. The targets of Kae and the differential genes of vitiligo were screened based on different databases. Besides, the protein-protein interaction (PPI) network of the common target of Kae and vitiligo was constructed to further identify the "keycluster" genes of the drug-disease interaction (DDI) network. In addition, the enrichment analysis based on Gene Ontolog

SUBMITTER: Li J 

PROVIDER: S-EPMC11904206 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature