ImmunoTar-integrative prioritization of cell surface targets for cancer immunotherapy.

ABSTRACT:

Motivation

Cancer remains a leading cause of mortality globally. Recent improvements in survival have been facilitated by the development of targeted and less toxic immunotherapies, such as chimeric antigen receptor (CAR)-T cells and antibody-drug conjugates (ADCs). These therapies, effective in treating both pediatric and adult patients with solid and hematological malignancies, rely on the identification of cancer-specific surface protein targets. While technologies like RNA sequencing and proteomics exist to survey these targets, identifying optimal targets for immunotherapies remains a challenge in the field.

Results

To address this challenge, we developed ImmunoTar, a novel computational tool designed to systematically prioritize candidate immunotherapeutic targets. Imm

SUBMITTER: Shraim R 

PROVIDER: S-EPMC11904301 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature