Single-cell RNA sequencing highlights the influence of innate and adaptive immune response mechanisms in psoriatic arthritis.

ABSTRACT:

Introduction

Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease displaying heterogeneous symptoms. However, the association between the clinical heterogeneity of PsA and disease immunopathogenesis remains poorly understood complicating diagnostic precision. A knowledge gap remains on whether it is possible to distinguish the clinical PsA phenotypes on the immune cellular level. The primary aim of the study was to explore the differences in gene expression profiles comparing PsA patients without cutaneous psoriasis (PsA-only) and PsA patients with cutaneous psoriasis (PsA/PsC). The secondary aim was to describe the transcriptional patterns in PsA patients compared with healthy controls.

Methods

The study applied single-cell RNA sequencing (scRNAseq) u

SUBMITTER: Nielsen MR 

PROVIDER: S-EPMC11904337 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature