Association of occupational physical activity and sedentary behaviour with the risk of hepatocellular carcinoma: a case-control study based on the Inpatient Clinico-Occupational Database of Rosai Hospital Group.

ABSTRACT:

Objectives

While there is growing evidence that physical activity reduces the risk of hepatocellular carcinoma (HCC), the impact of occupational physical activity and sedentary behaviour remains unclear. This study aimed to investigate the associations between occupational physical activity and sedentary behaviour and HCC risk.

Design

Matched case-control study.

Setting

Nationwide multicentre, hospital-inpatient data set in Japan, from 2005 to 2021.

Participants

The study included 5625 inpatients diagnosed with HCC and 27 792 matched controls without liver disease or neoplasms. Participants were matched based on sex, age, admission date, and hospital.

Primary measures

The association between levels of occupational physical activity (low, medium, high) an

SUBMITTER: Nakazawa S 

PROVIDER: S-EPMC11904348 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature