Treating critical bone defects by using core-shell biological scaffold to regulate Fibrosis-Osteogenic homeostasis.

ABSTRACT: Critical bone defects pose a significant challenge in the realm of bone defect repair. During the repair process, bone formation is crucial, as the occurrence of invasive tissue growth into the defect, known as fibrosis, is also a possibility. Excessive fibrosis can lead to a "filling effect," wherein fibrous tissue occupies the bone defect area, thereby impeding the bone formation and repair processes. Hence, regulating the dynamic balance between fibrosis and osteogenesis is pivotal to effectively treat critical bone defects. To mitigate the rapid fibrosis rate at the bone defect site, which may result in repair failure, we have devised and fabricated a biomimetic core-shell scaffold-PCL-FAPI/GelMA/HAMA-GBA@plasmid-knockdown SHN-3 (PCL-FAPI/GH-GBA@pk SHN-3)-aimed at modulating fibrosis a

SUBMITTER: Li Y 

PROVIDER: S-EPMC11904517 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature