Diagnostic Performance of Monocyte Distribution Width for the Detection of Sepsis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

To aggregate literature on the diagnostic performance of monocyte distribution width (MDW) for sepsis detection among adults in the emergency department and inpatient settings.

Methods

We searched the MEDLINE, EMBASE, SCOPUS, and Cochrane databases for studies evaluating MDW for sepsis diagnosis in adults in the hospital setting through October 19, 2024. Two authors (G.E. and Q.H.) independently performed eligibility assessment, data extraction, and risk of bias assessment. We evaluated performance for sepsis-2 and sepsis-3 separately and applied separate diagnostic thresholds depending on the anticoagulant used in blood collection. Data were pooled using a random-effects model. We performed multiple sensitivity analyses to evaluate the stability of our findings.<

SUBMITTER: Eisinger GJ 

PROVIDER: S-EPMC11904537 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature